Clinical and Scientific References

From Mcforadhd

RECENT CLINICAL STUDIES (2008)

Attention, Cannabis and Driving Performances: Cannabis Improves Symptoms of ADHD, P. Strohbeck-Kuehner and al., Cannabinoids 2008;3(1):1-3

"The authors also hypothesized that the effects of cannabinoids in [ADHD] patients may be different from those in healthy users suggesting an involvement of the central cannabinoid receptor systems in the pathology of the [ADHD] dosorder"

Mental Health: Different psychological effects of cannabis use in adolescences at genetic risk for schizophrenia and with ADHD

"...the cannabis users in the ADHD group had similar, or possibly lower, mental health scores than non-users."

Depression: Treating Depression with cannabinoids, K. Blass, Cannabinoids 2008;3(2):8-10

Anxiety : Action of Cannabidiol CBD on the anxiety and other effects produced by THC in normal subjects, Zuardi and al., Psychopharmacology, 1982;76(3):245-250.[1]

OTHER PUBLICATIONS

Endocannabinoid System and Synaptic Plasticity: Implications for the Emotional Responses : "... endocannabinoid signaling could represent a potential therapeutical tool in the treatment of both anxiety and depressive symptoms"[2]

Never fear, cannabinoids are Here, NATURE, Vol 418, Aug 2002 : "... But is seems possible that (cannabis) may instead be a form of self-medication for the sometimes extreme anxiety that (anxiety disorder people) experience"

Role of Endocannabinoids in Synaptic Signaling, D. Piomelli and al., Physiol. Rev. vol 83 10171066[3]

Cannabinoid Receptors in Microglia of the Central Nervous System : immune Functional Relevance, Cabral and al, Journal of Leukocyte Biology, vol 78, Dec 2005[4]

Chronic Microglial Activation and Excitotoxicity Secondary to Excessive Immune Stimulation ; Possible Factors in Gulf War Synrdome and Autism, Blaylock, Journal of American Physicians ans Surgeons, vol 9 (2) summer 2004[5]

STUDIES ON ADHD ANIMAL MODELS (rats-mice)

Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors, Moreira and Al., Neuropharmacology 54 (2008) 141-150[6]

Modulation of anxiety through blockage of anandamide hydrolysis, D Piomelli and al., Mature Medecine, vol 9, N°1, Jan. 2003[7]

The Endogenous Cannabinoid System controls extinction of aversive memories, G. Marsicano and al., NATURE, Vol 418, Aug 2002

Cannabinoid CB1 Receptor Mediates Fear Exctinction via Habituation-Like Processes, Kamprath and al., The Journal of Neuroscience, June 21, 2006, 26(25):6677-6686[8]

Enhancing Cannabinoid Neurotransmission Augments the Extinction of Conditioned Fear, Chhatwal and al., Neuropsychopharmacology (2005) 30, 516-524[9]

Facilitation of Contextual Fear Memory Extinction and Anti-anxiogenic Effects of AM404 and Cannabidiol CBD in Conditionned Rats, Bitencourt and al., 1st Annual Satellite Symposieum on the Cannabinoids

The Spontaneously Hypertensive-rat (SRH) as an Animal Model of ADHD : Evidence for Impulsive and non-impulsive Subpopulations, Adriani and al., Neuroscience and Behavioral Reviews, vol 27, Issue 7, Nov 2003, 639-651[10]

Cannabidiol CBD, extracted from Cannabis Sativa, selectively inhibits inflammatory hypermotility in mice, Capasso and al., British Journal of Pharmacology, 2008 Jul, 154(5), 1001-8[11]

ENDOCANNABINOID SYSTEM : THEORY : Endocannabinoid System Network ECSN (USA)

CANNABIS AND PHYTO-CANNABINOIDS CHEMISTRY : Extraction the Medicine, Arnaud Hazekamp Thesis (Netherlands)